GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12748152 | 1 | rs61457762 | chr1:27284157 | ZDHHC18 | chr1:27153201-27182207:+ | 0.61 | 6.72 | 5.28E-11 | HDL cholesterol;Triglycerides;LDL cholesterol |
| THCA | cis | rs2241437 | 1 | rs61477982 | chr2:86160532 | REEP1 | chr2:86441122-86564777:- | 0.25 | 3.41 | 0.000712 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs2129782 | 1 | rs61498756 | chr8:89455192 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs61142792 | 1 | rs61505517 | chr5:176982391 | DOK3 | chr5:176928915-176937427:- | 0.27 | 6.07 | 2.67E-9 | Alzheimer disease and age of onset |
| THCA | cis | rs2274273 | 1 | rs61508494 | chr14:55587297 | FBXO34 | chr14:55738021-55893431:+ | -0.14 | -3.49 | 0.000526 | Protein biomarker |
| THCA | cis | rs2274273 | 1 | rs61508494 | chr14:55587297 | KIAA0831 | chr14:55833110-55878576:- | -0.13 | -3.77 | 0.000187 | Protein biomarker |
| THCA | cis | rs6151429 | 1 | rs6151429 | chr22:51063477 | ARSA | chr22:51063450-51066607:- | -1.09 | -14.85 | 2.74E-41 | Blood metabolite levels |
| THCA | cis | rs1027730 | 1 | rs61515309 | chr8:94080589 | C8orf83 | chr8:93895865-94029901:- | 0.28 | 4.45 | 1.07E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs12780845 | 1 | rs61517255 | chr10:17208918 | TRDMT1 | chr10:17184983-17243681:- | -0.43 | -10.11 | 6.61E-22 | Homocysteine levels |
| THCA | cis | rs12780845 | 1 | rs61517255 | chr10:17208918 | VIM | chr10:17270258-17279592:+ | -0.19 | -3.49 | 0.000534 | Homocysteine levels |
| THCA | cis | rs61524473 | 1 | rs61524473 | chr15:45646283 | DUOXA1 | chr15:45409688-45422075:- | 0.13 | 4.12 | 4.41E-5 | Metabolite levels (small molecules and protein measures) |
| THCA | cis | rs61524473 | 1 | rs61524473 | chr15:45646283 | GATM | chr15:45653324-45670980:- | -0.17 | -4.07 | 5.62E-5 | Metabolite levels (small molecules and protein measures) |
| THCA | cis | rs61524473 | 1 | rs61524473 | chr15:45646283 | SPATA5L1 | chr15:45694519-45713614:+ | 0.72 | 16.12 | 5.47E-47 | Metabolite levels (small molecules and protein measures) |
| THCA | cis | rs7097 | 1 | rs615284 | chr13:28192930 | POLR1D | chr13:28194895-28241547:+ | -0.18 | -4.13 | 4.27E-5 | Large B-cell lymphoma |
| THCA | cis | rs7714584 | 1 | rs61530785 | chr5:150261364 | LOC134466 | chr5:150310000-150326146:- | 0.44 | 5.86 | 8.45E-9 | Crohn's disease |